Electroencephalographic Change of Non-affected Side of Hemimegalencephaly and Developmental Progress after Hemispherotomy

DOI Web Site 15 References
  • Takahashi Koji
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Nakagawa Eiji
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Takeshita Eri
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Motohashi Yuko
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Ishiyama Akihiko
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Saito Takashi
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Komaki Hirofumi
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Sugai Kenji
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)
  • Kita Yosuke
    Department of Developmental Disorders, National Institute of Mental Health, NCNP
  • Takahashi Akio
    Department of Neurosurgery, National Center Hospital, NCNP
  • Otsuki Taisuke
    Department of Neurosurgery, National Center Hospital, NCNP
  • Sasaki Masayuki
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP)

Bibliographic Information

Other Title
  • 片側巨脳症における半球離断術後の非罹患側の脳波経過と発達

Search this article

Description

<p>Hemimegalencephaly is characterized by severe psychomotor impairment and intractable epilepsy, which is often requires a hemispherotomy. After hemispherotomy, epileptic discharges may sometimes occur in the non-affected hemisphere even when clinical seizures do not recur for a long time. We evaluated six cases of hemimegalencephaly after hemispherotomy with a seizure-free period lasting at least 36 months, which we could track using video-electroencephalography. Developmental age (DA) and developmental quotient (DQ) were evaluated using the developmental check- list (Kinder Infant Developmental Scale). We found the DQ declined and the total DA increased in all cases. To study the correlation between DA and epileptic discharges in the non-affected hemisphere, we measured the paroxysmal-index (PI) the number of one-second bins containing one or more epileptic discharges in the non-affected hemisphere, divided by the total number of seconds. The PI and DA data were collected at the same time during every regularly-scheduled evaluation. We calculated the rate of change of PI and DA. Interestingly, expressive language development and PI were negatively correlated when the PI increased at a rate above average. The receptive language DA and PI was not correlated. This finding suggests the expressive language development delay may worsen when epileptic discharges of non-affected side increase.</p>

Journal

References(15)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top