Transient Measurement of Glucose Using On-Off Controllable Enzyme Electrode with Polypyrrole Membrane.
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- Miyasaka Takehiro
- Department of Chemical Engineering, Waseda University
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- Yoshimi Yasuo
- Department of Chemical Engineering, Waseda University
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- Sakai Kiyotaka
- Department of Chemical Engineering, Waseda University
書誌事項
- タイトル別名
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- Transient Measurement of Glucose Using
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A glucose sensor, using glucose oxidase immobilized in an electrically conductive polymer membrane, is developed for transient-mode measurement by on-off reaction control in the present work. An implantable glucose sensor loses its stability under the skin by fouling resulting from fibroblast adhesion on the glucose oxidase-immobilized membrane. Change in glucose distribution inside the membrane and in the vicinity of the surface of the membrane resulting from the fouling makes the measurement of the glucose concentration unstable. A technique of measuring transient current of the glucose sensor after activation of glucose oxidase may hardly be affected by the fouling as oxidation of coenzyme of glucose oxidase is rapid and the transient current is sensitive to glucose concentration. A glucose sensor with glucose oxidase immobilized in an electrically conductive polypyrrole membrane was fabricated. The activity of the glucose oxidase is switched on and off by a stepwise change of potential of the polypyrrole membrane from 0.15 V to 0.45 V versus a saturated calomel electrode. The two conditions described above can be confirmed by measuring transient current. Current increased momentarily after activation of glucose oxidase and decreased moderately after that. The oxidation and reduction of glucose oxidase is sufficiently rapid, and current intensity depends on glucose concentration in the test solution.
収録刊行物
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- JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
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JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 31 (1), 29-34, 1998
公益社団法人 化学工学会
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詳細情報 詳細情報について
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- CRID
- 1390001204566783232
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- NII論文ID
- 10002064804
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- NII書誌ID
- AA00709658
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- COI
- 1:CAS:528:DyaK1cXhvV2qsrw%3D
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- ISSN
- 18811299
- 00219592
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- NDL書誌ID
- 4427698
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可