Current status and unsolved problems about cetuximab plus radiation for head and neck cancer

DOI
  • KIYOTA Naomi
    Department of Medical Oncology and Hematology, Kobe University Hospital

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Other Title
  • CRT と BRT の使い分け―セツキシマブ-RTの現状と問題点―

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Description

<p>The standard non-surgical treatment for locally advanced head and neck squamous cell carcinoma is concurrent chemoradiotherapy with cisplatin (CDDP) since previous pivotal phase Ⅲ trials and meta-analyses showed the survival benefit of CDDP plus radiation. On the other hand, adding cetuximab to radiation (RT) also showed the survival benefit comparing with RT alone. So, we are now facing the clinical question whether cetuximab plus RT is equivalent to CDDP plus RT or not. At present, we have to wait for the ongoing randomized clinical trials comparing CDDP plus RT with cetuximab plus RT and recommend CDDP + RT to the patient in good general condition with adequate organ function.</p>

Journal

  • jibi to rinsho

    jibi to rinsho 61 (Suppl.1), S3-S8, 2015-11-20

    JIBI TO RINSHO KAI

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