A Facile Synthesis of Optically Active 1,1,1-Trifluoro-3-alkyn-2-ols by Stereospecific Substitution of Optically Active 1-Benzyloxy-2,2,2-trifluoroethyl Tosylate with Lithium Alkynyltriethylaluminates
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- Matsutani Hiroshi
- Sagami Chemical Research Center
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- Kusumoto Tetsuo
- Sagami Chemical Research Center
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- Hiyama Tamejiro
- Department of Material Chemistry, Graduate School of Engineering, Kyoto University
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Description
Optically active 1-benzyloxy-2,2,2-trifluoroethyl tosylate reacts with various lithium alkynyltriethylaluminates to give optically active 2-benzyloxy-1,1,1-trifluoro-3-alkynes selectively and stereospecifically with inversion of configuration. Thus, the reaction provides with a novel method for the preparation of various optically active 1,1,1-trifluoro-3-alkyn-2-ols.
Journal
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- Chemistry Letters
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Chemistry Letters 28 (6), 529-530, 1999
The Chemical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204576664064
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- NII Article ID
- 10004486441
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- NII Book ID
- AA00603318
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- COI
- 1:CAS:528:DyaK1MXjs1Oju7s%3D
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- ISSN
- 13480715
- 03667022
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed