An Effective Synthesis of a (Pyridin-3-yl)isoxazole via 1,3-Dipolar Cycloaddition Using ZnCl2: Synthesis of a (2-Aminopyridin-3-yl)isoxazole Derivative and Its Antifungal Activity
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- Tanaka Keigo
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Inoue Satoshi
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Murai Norio
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Shirotori Syuji
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Nakamoto Kazutaka
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Abe Shinya
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Horii Takaaki
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Miyazaki Mamiko
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Hata Katsura
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Watanabe Naoaki
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Asada Makoto
- Discovery Research Laboratories, Eisai Co., Ltd.
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- Matsukura Masayuki
- Discovery Research Laboratories, Eisai Co., Ltd.
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説明
We described a rare example of an effective isoxazole synthesis via a 1,3-dipolar cycloaddition using ZnCl2, which allowed us to synthesize novel (2-aminopyridin-3-yl)isoxazole derivatives effectively. In addition, these compounds demonstrated potent antifungal activity in vitro against both Candida albicans and Aspergillus fumigatus.
収録刊行物
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- Chemistry Letters
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Chemistry Letters 39 (10), 1033-1035, 2010
公益社団法人 日本化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204584304000
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- NII論文ID
- 10027185362
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- NII書誌ID
- AA00603318
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- ISSN
- 13480715
- 03667022
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
