Pharmacological study on regulatory effect of neuro-peptides, cholecystokinin-octapeptide and its analogue ceruletide, on the salivary response induced by autonomimetic drugs in mice.

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  • Ohkubo Noboru
    Department of Dental Pharmacology, School of Dentistry, Iwate Medical University

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  • 神経ペプチドのマウス唾液分泌反応の調節に及ぼす影響の研究
  • ― cholecystokinin-octapeptide およびその近縁物質 ceruletide の自律神経作動薬による唾液分泌反応に関する薬理学的解析―

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Abstract

<p>Effects of neuropeptides, cholecystokinin-octapeptide (CCK-8:5,50,500 μg/kg, s. c.) and its analogue ceruletide (Cer: 0.4,4,40 μg/㎏, s. c.), on the salivary responses induced by autonomimetic drugs in mice were analyzed in a pharmacological manner.</p><p>It was found that CCK-8 further stimulated an increased response to the pilocarpine (0,8 ㎎/kg, s.c.) -induced saivation in the cholinergic nervous system. Cer further stimulated response to the dobutamine (10 ㎎/kg, s. c.) -induced salivation, but not to salbutamol (40 ㎎/㎏, s. c.), in the adrenergic nervous system. On the other hand, CCK-8 and Cer showed no effects on the phenylephrine (5 ㎎/kg, s. c.) -and clonidine (5 ㎎/kg, s. c.) -induced salivation in the adrenergic nervous system. Thus, it suggests that CCK-8 has a different effect compared to Cer on the responses to the salivary secretion induced by autonomimetic drugs in mice.</p>

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