CMOS Imaging Device for Optical Imaging of Biological Activities

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  • Shishido Sanshiro
    Graduate School of Materials Science, Nara Institute of Science and Technology
  • Oguro Yasuhiro
    Graduate School of Materials Science, Nara Institute of Science and Technology
  • Noda Toshihiko
    Graduate School of Materials Science, Nara Institute of Science and Technology JST-CREST
  • Sasagawa Kiyotaka
    Graduate School of Materials Science, Nara Institute of Science and Technology JST-CREST
  • Tokuda Takashi
    Graduate School of Materials Science, Nara Institute of Science and Technology JST-CREST
  • Ohta Jun
    Graduate School of Materials Science, Nara Institute of Science and Technology JST-CREST

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  • 光を用いた脳活動計測用ＣＭＯＳイメージングデバイスの開発
  • ヒカリ オ モチイタ ノウ カツドウ ケイソクヨウ CMOS イメージングデバイス ノ カイハツ

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Abstract

In this paper, we propose a CMOS image sensor device placed on the brain surface or cerebral sulcus (Fig. 1). The device has a photo detector array where a single optical detector is usually used. The proposed imaging device enables the analysis which reflects a surface blood pattern in the observed area. It is also possible to improve effective sensitivity by image processing and to simplify the measurement system by the CMOS sensor device with on-chip light source. We describe the design details and characterization of proposed device. We also demonstrate detection of hemoglobin oxygenation level with external light source, imaging capability of biological activities, and image processing for sensitivity improvement is also realized.

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