Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus.
書誌事項
- タイトル別名
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- Antiemetic Effects of Morphine on Motio
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抄録
Emetic and antiemetic effects of morphine were investigated in Suncus murinus. Subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 μg) of morphine failed to cause emesis. However, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), copper sulfate (40 mg/kg, p.o.), cisplatin(20 mg/kg, i.p.) and motion stimulus. These results suggest that morphine has only antiemetic potency and may block a common mechanism for the emetic reflex of suncus, because the antiemetic effects of the drug were exerted irrespective of the stimulus.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 20 (7), 739-742, 1997
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204621031808
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- NII論文ID
- 110003639138
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK2sXkslygt7Y%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 4260454
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- PubMed
- 9255411
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可