Pharmacokinetics of a Chinese Traditional Medicine, Danshensu (3, 4-Dihydroxyphenyllactic Acid), in Rabbits Using High-Performance Liquid Chromatography.
書誌事項
- タイトル別名
-
- Pharmacokinetics of a Chinese Tradition
この論文をさがす
抄録
An injectable solution of Danshen was prepared and its in vivo disposition was examined in rabbits. The presence of Danshensu, one of the active components of Danshen, in the obtained solution was confirmed by a simple high-performance liquid chromatographic (HPLC) method. The pharmacokinetics of Danshensu in rabbits was evaluated by the HPLC method for plasma Danshensu. The calibration curve for Danshensu was linear (r=0.998) over the concentration range of 0.25-40.0 μg/ml. The intra-assay coefficients of variation (CVs) were 3.8, 3.1, and 3.1% at 1, 10, and 50 μg/ml, respectively, and the inter-assay CVs were 5.3, 5.3, and 2.9% at 1, 10, and 50 μg/ml, respectively. The analytical recovery of Danshensu in plasma averaged 95.2%. From the plasma concentraion profile of Danshensu after its intravenous administration, the t1/2, mean residence time (MRT), Vdss, and Cl<tot> were determined as 32 min, 48 min, 149 ml/kg, and 3.13 ml/min/kg, respectively.
収録刊行物
-
- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
-
Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 20 (3), 285-287, 1997
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204621358720
-
- NII論文ID
- 110003639041
-
- NII書誌ID
- AA10885497
-
- COI
- 1:CAS:528:DyaK2sXitVKgtLo%3D
-
- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
-
- NDL書誌ID
- 4163695
-
- PubMed
- 9084889
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可