Effect of Pulsed Output Ultrasound on the Transdermal Absorption of Indomethacin from an Ointment in Rats.
書誌事項
- タイトル別名
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- Effect of Pulsed Output Ultrasound on t
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The effect of pulsed output ultrasound (1 MHz) with on/off ratios of 1 : 2, 1 : 4 and 1 : 9 on transdermal absorption of indomethacin from an ointment was studied in rats. Ultrasound energy was supplied for between 10 and 19 min at a range of intensities (1.0-2.5 W·cm-2), energy levels commonly used for therapeutic purposes. The on/off pulsed ratio, intensity and the time of application were found to play an important role in the transdermal phonophoretic delivery system of indomethacin; 1 : 2 pulsed output ultrasound appeared to be the most effective in improving the transdermal absorption. The highest penetration was observed at an intensity of 1.0 W·cm-2 and application time of 15 min. With pulsed output it was possible to use higher intensities of ultrasound without increasing skin temperature or damaging skin.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 20 (3), 288-291, 1997
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204621359872
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- NII論文ID
- 110003639042
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK2sXitVKgtLg%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 4163696
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- PubMed
- 9084890
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可