Involvement of the Rapid Increase in cAMP Content in the Vanadate-Stimulated Release of Lipoprotein Lipase Activity from Rat Fat Pads.
書誌事項
- タイトル別名
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- Involvement of the Rapid Increase in cA
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説明
Mechanisms of the stimulatory release of lipoprotein lipase (LPL) activity from isolated rat fat pads by sodium orthovanadate (vanadate) were studied through a cAMP-dependent process. A potent inhibitor of insulin receptor tyrosine kinase, quercetin, inhibited the vanadate-increasing effect on the LPL activity in fat pads, but did not inhibit the vanadate-stimulated release of LPL activity from the fat pads. Proparanolol and N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) decrased the vanadate-stimulated release in a dose-dependent manner. Isoproterenol and dibutyryl cAMP (Bt2cAMP) stimulated the release of LPL activity from fat pads. Vanadate, as well as isoproterenol, rapidly increased the cAMP content in fat pads, and this increase was almost completely inhibited by propranolol. Vanadate increased the cAMP-dependent protein kinase (PKA) activity ratios calculated from the measurement in the presence or absence of cAMP or PKA inhibitor.There results suggest that the vanadate-stimulated release of LPL activity is associated with a process involving a rapid increase in the cAMP content accompanied by the activation of PKA.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 19 (11), 1412-1416, 1996
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204623295488
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- NII論文ID
- 110003663338
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK28Xnt1Oqtbc%3D
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- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
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- NDL書誌ID
- 4080079
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- PubMed
- 8951155
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可