Novel Linkage Disequilibrium of Single Nucleotide Polymorphisms in the Transcriptional Regulatory Region of .MU.-Opioid Receptor Gene in Japanese Population

Ono Takeshi, Muto Akihiro, Kaneda Toshio, Arita Eri, Yoshida Tadashi

doi:10.1248/bpb.32.721

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Novel linkage disequilibrium of single nucleotide polymorphisms in the transcriptional regulatory region of μ-opioid receptor gene in Japanese population
Novel linkage disequilibrium of single nucleotide polymorphisms in the transcriptional regulatory region of m opioid receptor gene in Japanese population

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μ-Opioid receptor agonists, such as morphine, are widely applied in pain therapy clinical practice. However, the effects exerted by morphine via receptor are influenced by individual specificity. Single nucleotide polymorphisms (SNPs) in μ-opioid receptor gene (OPRM1) have been reported to influence receptor expression and function. Subsequently, we analyzed SNPs frequency and linkage disequilibrium associated with OPRM1 transcriptional region and 4 exons among healthy Japanese individuals. Consequently, we detected 10 SNPs (−1748G/A, −1565T/C, −1045A/G, −172G/T, −38C/A, 118A/G, ivs2+31 G/A, ivs2+691 C/G, ivs4+274 A/G, and ivs4+435 G/A). Moreover, linkage analysis revealed novel linkage between −1748G/A and −172G/T, which was not observed in studies performed in other nations. In contrast, SNPs frequency detected in this study was similar to previously reported results on Asians; however, linkage disequilibrium reports from different nations differed. These results possibly provide useful information for OPRM1 genotyping in the Japanese population.

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Biological and Pharmaceutical Bulletin

Biological and Pharmaceutical Bulletin 32 (4), 721-723, 2009

The Pharmaceutical Society of Japan

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