Vasodilator Effects of Ibudilast on Retinal Blood Vessels in Anesthetized Rats

DOI Web Site Web Site PubMed 4 Citations 26 References
  • Noguchi Masahiro
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Mori Asami
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Sakamoto Kenji
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Nakahara Tsutomu
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
  • Ishii Kunio
    Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences

Search this article

Abstract

Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal blood vessels in rats in vivo. Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)). Retinal vascular images were captured with a fundus camera system for small animals, and the diameter of retinal blood vessels was measured. Ibudilast (0.1 and 1 mg/kg, intravenously (i.v.)) elicited a sustained increase in the diameter of retinal blood vessels and heart rate without altering systemic blood pressure. The effects of ibudilast were significantly reduced by treatment with the nonselective cyclooxygenase inhibitor indomethacin (5 mg/kg, i.p.). These results suggest that ibudilast dilates retinal blood vessels through cyclooxygenase-dependent mechanisms in rats in vivo.

Journal

Citations (4)*help

See more

References(26)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top