The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-κB Activation in RAW264.7 Macrophage Cells
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- Jin Meihua
- College of Pharmacy, Yeungnam University
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- Moon Tae Chul
- Pulmonary Research Group, Department of Medicine, University of Alberta
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- Quan Zhejiu
- College of Pharmacy, Yeungnam University
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- Lee Eunkyung
- Daegu Gyeongbuk Institute for Oriental Medicine Industry
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- Kim Yun Kyung
- College of Pharmacy, Yeungnam University
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- Yang Ju Hae
- College of Pharmacy, Yeungnam University
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- Suh Seok-Jong
- Department of Biological Science, Sungkyunkwan University
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- Jeong Tae Cheon
- College of Pharmacy, Yeungnam University
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- Lee Seung Ho
- College of Pharmacy, Yeungnam University
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- Kim Cheorl-Ho
- Department of Biological Science, Sungkyunkwan University
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- Chang Hyeun Wook
- College of Pharmacy, Yeungnam University
書誌事項
- タイトル別名
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- The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-κB Activation in RAW264.7 Macrophage Cells
- The naturally occurring flavolignan deoxypodophyllotoxin inhibits lipopolysaccharide induced iNOS expression through the NF kB activation in RAW264 7 macrophage cells
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Deoxypodophyllotoxin (DPT), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from Anthriscus sylvestris HOFFM., and we examined its effects on the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated, murine macrophage-like RAW264.7 cells. Western blot analysis performed with specific anti-iNOS antibodies showed that a decrease in nitric oxide (NO) was accompanied by a decrease in the iNOS protein level. To clarify the mechanistic basis for DPT's ability to inhibit iNOS induction, we examined the effect of DPT on nuclear factor (NF)-κB transcriptional activity and DNA binding activity. DPT potently suppressed both reporter gene activity and DNA binding activity. These findings suggest that DPT in RAW264.7 cells abolished LPS-induced iNOS expression by inhibiting the transcription factor, NF-κB.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 31 (7), 1312-1315, 2008
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204624687488
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- NII論文ID
- 110006792094
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 9544762
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可