Effects of a New Antiallergic Drug, VUF-K-8788, on Infiltration of Lung Parenchyma by Eosinophils in Guinea Pigs and Eosinophil-Adhesion to Human Umbilical Vein Endothelial Cells (HUVEC).

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  • TAKIZAWA Toshiaki
    Department of Pharmacology, Gifu Pharmaceutical University Tokyo Research Laboratories, Kowa Company Ltd.
  • WATANABE Chie
    Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
  • SAIKI Ikuo
    Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
  • WADA Yasushi
    Tokyo Research Laboratories, Kowa Company Ltd.
  • TOHMA Tsutomu
    Tokyo Research Laboratories, Kowa Company Ltd.
  • NAGAI Hiroichi
    Department of Pharmacology, Gifu Pharmaceutical University

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Airway inflammation and reversible airway obstruction are hallmarks of bronchial asthma. In this study, we investigated the effects of a new antiallergic drug, 7-{3-[4-(2-quinolinylmethyl)-1-piperazinyl]-propoxy}-2,3-dihydro-4H-1,4-benzothiazin-3-one (VUF-K-8788), on histopathological changes in lung parenchyma of guinea pigs during late-phase asthmatic reaction (LAR), and on eosinophil-adhesion to human umbilical vein endothelial cells (HUVEC). <br>Repeated exposure to ovalbumin of sensitized guinea pigs induced inflammatory phenomena such as hyperplasia of airway epithelial cells, perivascular edema and infiltration of lung parenchyma by eosinophils. VUF-K-8788 inhibited these histopathological phenomena at 10 mg/kg p.o. Moreover, the eosinophil-adherence to HUVEC was inhibited by VUF-K-8788 at the concentration of 10—30 μM. In conclusion, this inhibitory effect of VUF-K-8788 on eosinophil-adherence might contribute to the prevention of LAR and infiltration by eosinophils in the experimental asthmatic model in guinea pigs.

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