Effect of Chondroitinase on Dermatan Sulfate-Facilitated Arginine Amidase Released from Rabbit Ear Artery
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- Ishii-Nozawa Reiko
- Department of Clinical Pharmacology, Meiji Pharmaceutical University
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- Naito Tatsuya
- Department of Clinical Pharmacology, Meiji Pharmaceutical University
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- Mita Mitsuo
- Department of Pharmacodynamics, Meiji Pharmaceutical University
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- Miyazaki Kyosuke
- Seikagaku Kogyo Co.
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- Matsuda Yoshifumi
- Department of Functional Bioanalysis, Meiji Pharmaceutical University
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- Takeuchi Koichi
- Department of Clinical Pharmacology, Meiji Pharmaceutical University
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Abstract
We examined the effects of chondroitinases on the release of dermatan sulfate (DS)-induced arginine amidase (AA) from rabbit ear artery. DS-induced AA release was significantly decreased by treatment with chondroitinase ABC (ABCase) in the rabbit ear artery. On the other hand, Chondroitinase ACII (ACIIase) enhanced spontaneous and DS-induced AA release. Heat-inactivated ABCase and ACIIase did not affect spontaneous and DS-induced AA release. Furthermore, ABCase, but not ACIIase and heat-inactivated chondroitinases, degraded DS. These results indicate that the facilitatory effect of DS-induced AA release from the rabbit ear artery is affected by the molecular size of DS.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 33 (1), 150-152, 2010
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204624818176
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- NII Article ID
- 130000140211
- 40016900233
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 10497697
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
