Anti-proliferative Effect of Licochalcone A on Vascular Smooth Muscle Cells
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- Park Jin-Hee
- Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, NIH
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- Lim Hyun Joung
- Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, NIH
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- Lee Kuy-Sook
- Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, NIH
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- Lee Seahyoung
- Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, NIH
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- Kwak Hyun-Jeong
- Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, NIH
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- Cha Jeong-Heon
- Department of Oral Biology, BK21 Project, Oral Science Research Center, Yonsei University College of Dentistry
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- Park Hyun-Young
- Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, NIH
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Description
Licochalcone A, a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 μM licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G1 to S phase. In addition, 5 μM licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27kip1 expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 31 (11), 1996-2000, 2008
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204624970880
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- NII Article ID
- 110006968076
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 9685306
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed