Central in Vivo Nicotinic Acetylcholine Receptor Imaging Agents for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT)
-
- Ogawa Mikako
- Photon Medical Research Center, Hamamatsu University School of Medicine
-
- Tsukada Hideo
- Central Research Laboratory, Hamamatsu Photonics K.K.
-
- Hatano Kentaro
- National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology
-
- Ouchi Yasuomi
- Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine
-
- Saji Hideo
- Graduate School of Pharmaceutical Sciences, Kyoto University
-
- Magata Yasuhiro
- Photon Medical Research Center, Hamamatsu University School of Medicine Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine
この論文をさがす
抄録
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are useful for non-invasive investigation of brain receptors. With these imaging techniques, changes in brain receptor densities and distributions during chronic drug treatments and disease progressions can be tracked for a long period. Appropriate radiolabeled imaging agents are necessary for PET and SPECT molecular imaging. Nicotinic acetylcholine receptors (nAChRs) play important roles in brain functions. The α4β2 and α7 are the major nAChR subtypes in the brain. To date, several subtype selective radiolabeled ligands for nAChR have been reported. For the α4β2 subtype, some agents are already applied for human studies, but only a few agents are developed for the α7 subtype. Here, we overview our results of [125/123I]5-iodo-3-(2(S)-azetidinylmethoxy)pyridine and 5-[11C]methyl-3-(2-(S)-azetidinylmethoxy)pyridine ([11C]5MA) for α4β2 subtype imaging, and [11C](R)-2-methylamino-benzoic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester ([11C](R)-MeQAA) for α7 subtype imaging.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 32 (3), 337-340, 2009
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204625121152
-
- NII論文ID
- 110007122751
-
- NII書誌ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 10166177
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可