Innovative Preparation of Curcumin for Improved Oral Bioavailability

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  • Sasaki Hiroki
    Theravalues Corporation
  • Sunagawa Yoichi
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization Department of Human Health Sciences, Graduate School of Medicine, Kyoto University Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • Takahashi Kenji
    Theravalues Corporation
  • Imaizumi Atsushi
    Theravalues Corporation
  • Fukuda Hiroyuki
    Theravalues Corporation
  • Hashimoto Tadashi
    Theravalues Corporation
  • Wada Hiromichi
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization
  • Katanasaka Yasufumi
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
  • Kakeya Hideaki
    Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
  • Fujita Masatoshi
    Department of Human Health Sciences, Graduate School of Medicine, Kyoto University
  • Hasegawa Koji
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization
  • Morimoto Tatsuya
    Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka

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Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects. We have successfully developed a highly absorptive curcumin dispersed with colloidal nano-particles, and named it THERACURMIN. The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentration–time curve (AUC) after the oral administration of THERACURMIN was found to be more than 40-fold higher than that of curcumin powder in rats. Then, healthy human volunteers were administered orally 30 mg of THERACURMIN or curcumin powder. The AUC of THERACURMIN was 27-fold higher than that of curcumin powder. In addition, THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood. These findings demonstrate that THERACURMIN shows a much higher bioavailability than currently available preparations. Thus, THERACURMIN may be useful to exert clinical benefits in humans at a lower dosage.

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