Inhibitory Effects of Ginsenosides and Their Hydrolyzed Metabolites on Daunorubicin Transport in KB-C2 Cells
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- Kitagawa Shuji
- Kobe Pharmaceutical University
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- Takahashi Tomoharu
- Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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- Nabekura Tomohiro
- Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences
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- Tachikawa Eiichi
- School of Medicine, Iwate Medical University
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- Hasegawa Hideo
- Fermenta Herb Institute Inc.
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We studied the effects of ginsenosides and their metabolites on daunorubicin transport in multidrug-resistant P-glycoprotein (P-gp)-overexpressing KB-C2 cells. Ginsenoside Rg1, which is a protopanaxatriol-type ginseng saponin, did not have any effects on the accumulation of P-gp substrate daunorubicin. On the other hand, its metabolite M4, which has no sugar moiety, increased the accumulation 3.6-fold at 5 μM. Metabolites of protoanaxadiol-type saponin M1 and M12 also increased accumulation, but the effects were less than that of M4. The findings showed larger effects of metabolites without glucose moieties. Analysis of verapamil-stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of P-gp.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 30 (10), 1979-1981, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204625174400
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- NII論文ID
- 110006436390
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8919697
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可