Oxidized low density lipoprotein: what is understood and what remains to be clarified
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- Itabe Hiroyuki
- Department of Molecular Pathology, Pharmaceutical Sciences, Teikyo University
書誌事項
- タイトル別名
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- Oxidized Low-density Lipoproteins: What Is Understood and What Remains to Be Clarified.
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抄録
Oxidized low-density lipoprotein (OxLDL) has previously been thought to promote atherogenesis through foam cell formation. However, the actual nature of OxLDL present in vivo remained obscure until recently. We have produced a monoclonal antibody, DLH3, which specifically binds to OxLDL but not to native LDL. The presence of OxLDL in the LDL fraction of human plasma was demonstrated by introducing a sandwich ELISA procedure using DLH3 together with an anti-apoB antibody. Furthermore, OxLDL levels appeared to increase in certain pathological conditions including acute myocardial infarction and carotid artery atherosclerosis. Accumulation of OxLDL in atherosclerotic lesions has also been demonstrated by immunohistochemical and biochemical studies using the DLH3 antibody. This antibody recognizes oxidized phosphatidylcholines (OxPC) generated during oxidative modification of LDL, and OxPC-apoB adducts formed in OxLDL are the presumed antigens. Measuring OxLDL in plasma would be a useful diagnostic tool for cardiovascular diseases. However, there still remain some major questions related to OxLDL, the answers to which are crucial for understanding the mechanisms of atherogenesis.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 26 (1), 1-9, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204625368192
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- NII論文ID
- 110003608279
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- NII書誌ID
- AA10885497
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- DOI
- 10.1248/bpb.26.1
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- COI
- 1:CAS:528:DC%2BD3sXjs1ejtLw%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6393515
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- PubMed
- 12520163
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可