Effects of Sucralfate on Gastric Irritant-Induced Necrosis and Apoptosis in Cultured Guinea Pig Gastric Mucosal Cells.
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- Hoshino Tatsuya
- Faculty of Pharmaceutical Sciences, Okayama University
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- Takano Tatsunori
- Faculty of Pharmaceutical Sciences, Okayama University
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- Tomisato Wataru
- Faculty of Pharmaceutical Sciences, Okayama University
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- Tsutsumi Shinji
- Faculty of Pharmaceutical Sciences, Okayama University
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- Hwang Hyun-Jung
- Faculty of Pharmaceutical Sciences, Okayama University
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- Koura Yuko
- Faculty of Pharmaceutical Sciences, Okayama University
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- Nishimoto Kiyo
- Faculty of Pharmaceutical Sciences, Okayama University
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- Tsuchiya Tomofusa
- Faculty of Pharmaceutical Sciences, Okayama University
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- Mizushima Tohru
- Faculty of Pharmaceutical Sciences, Okayama University PRESTO, Japan Science and Technology Corporation
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Description
We previously reported that several gastric irritants, including ethanol, hydrogen peroxide, and hydrochloric acid, induced both necrosis and apoptosis in cultured gastric mucosal cells. In the present study, we examined the effects of sucralfate, a unique gastroprotective drug, on gastric irritant-induced necrosis and apoptosis produced in vitro. Sucralfate strongly inhibited ethanol-induced necrosis in primary cultures of guinea pig gastric mucosal cells. The preincubation of cells with sucralfate was not necessary for its cytoprotective effect to be observed, thus making its mechanism of action different from that of other gastroprotective drugs. Necrosis of gastric mucosal cells induced by hydrogen peroxide or indomethacin was also suppressed by sucralfate. On the other hand, sucralfate only weakly inhibited ethanol-induced apoptosis. These results suggest that the cytoprotective effect of sucralfate on gastric mucosa in vivo can be explained, at least in part, by its inhibitory effect on gastric irritant-induced necrosis.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 26 (1), 24-27, 2003
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204625389056
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- NII Article ID
- 110003608282
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3sXjs1ejtLs%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6393570
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- PubMed
- 12520166
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed