Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga <i>Sargassum micracanthum</i>, and a New Chromene Derivative Converted from the Plastoquinones
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- Iwashima Makoto
- Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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- Mori Jun
- Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
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- Ting Xiang
- Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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- Matsunaga Takayuki
- Toyama Prefectural Institute for Pharmaceutical Research
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- Hayashi Kyoko
- Faculty of Medicine, Toyama Medical and Pharmaceutical University
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- Shinoda Daishi
- Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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- Saito Haruo
- Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
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- Sankawa Ushio
- Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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- Hayashi Toshimitsu
- Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
Bibliographic Information
- Other Title
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- Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga Sargassum micracanthum, and a New Chromene Derivative Converted from the Plastoquinones
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Description
Two plastoquinones were isolated from the methanolic extract of the brown alga Sargassum micracanthum, and these were identified as a known 2-geranylgeranyl-6-methylbenzoquinone and its hydroquinone, respectively, based on spectroscopic analysis. The absolute configuration of the secondary hydroxyl group was determined by the modified Mosher's method using the new chromene derivative converted from plastoquinones. One of the plastoquinones and the chromene exhibited significant antioxidant activities, such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). The benzoquinone-type compound and the chromene derivative were found to have potent antiviral activity against human cytomegalovirus (HCMV).
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 28 (2), 374-377, 2005
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204625424000
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- NII Article ID
- 110003665836
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
- http://id.crossref.org/issn/00092363
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- NDL BIB ID
- 7234030
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- PubMed
- 15684504
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed