Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga <i>Sargassum micracanthum</i>, and a New Chromene Derivative Converted from the Plastoquinones

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  • Iwashima Makoto
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Mori Jun
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
  • Ting Xiang
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Matsunaga Takayuki
    Toyama Prefectural Institute for Pharmaceutical Research
  • Hayashi Kyoko
    Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • Shinoda Daishi
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Saito Haruo
    Department of Pharmaceutical Research, Lead Chemical Co., Ltd.
  • Sankawa Ushio
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Hayashi Toshimitsu
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

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  • Antioxidant and Antiviral Activities of Plastoquinones from the Brown Alga Sargassum micracanthum, and a New Chromene Derivative Converted from the Plastoquinones

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Two plastoquinones were isolated from the methanolic extract of the brown alga Sargassum micracanthum, and these were identified as a known 2-geranylgeranyl-6-methylbenzoquinone and its hydroquinone, respectively, based on spectroscopic analysis. The absolute configuration of the secondary hydroxyl group was determined by the modified Mosher's method using the new chromene derivative converted from plastoquinones. One of the plastoquinones and the chromene exhibited significant antioxidant activities, such as an inhibitory effect on lipid peroxidation and a radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH). The benzoquinone-type compound and the chromene derivative were found to have potent antiviral activity against human cytomegalovirus (HCMV).

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