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- Go Eun Kyung
- Department of Pharmacy, College of Pharmacy
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- Jung Kyung Jin
- Department of Pharmacy, College of Pharmacy
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- Kim Ji Min
- Department of Pharmacy, College of Pharmacy
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- Lim Hyunae
- Department of Pharmacy, College of Pharmacy
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- Lim Hyeang Kwan
- Department of Pharmacy, College of Pharmacy
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- Yu Byung Pal
- Longevity Life Science and Technology Institutes, Pusan National University Department of Physiology, The University of Texas Health Science Center at San Antonio
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- Chung Hae Young
- Department of Pharmacy, College of Pharmacy Longevity Life Science and Technology Institutes, Pusan National University
書誌事項
- タイトル別名
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- Betaine Modulates Age-Related NF-.KAPPA.B by Thiol-Enhancing Action
- Betaine modulates age related NF kB by thiol enhancing action
- Betaine modulates age-related NF-B by thiol-enhancing action
この論文をさがす
説明
Depletion of glutathione levels and perturbations in redox status are considered to play a crucial role in aging and chronic inflammatory processes through the activation of redox sensitive transcription factors, including nuclear factor-κB (NF-κB). In the current study, we assessed the regulatory action of dietary betaine in the suppression of NF-κB by comparing kidney tissue from old, betaine-supplemented rats or non-betaine-supplemented rats (age 21 months) and 7 month-old rats. In addition, cultured HEK 293T cells were utilized for the molecular assessment of betaine's restorative ability of redox status when treating cells with potent glutathione (GSH)-depleting agents. Results showed that in old rats a short-term feeding (10 d) with betaine attenuated the age-related decrease in thiol levels, increase in reactive species and TNFα expression via NF-κB activation, compared to the young controls. These findings were verified in the cell-cultured system. Further investigations found that redox imbalance due to thiol depletion caused increased NF-κB activation, and cyclooxygenase (COX)-2 and TNFα levels, both of which were suppressed by betaine treatment. Based on both in vivo and in vitro data, we concluded that betaine exerts its efficacy by maintaining thiol status in the regulation of COX-2 and TNFα via NF-κB activation during aging.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 30 (12), 2244-2249, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204625440128
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- NII論文ID
- 110006546419
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 9274181
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可