Betaine modulates age-related NF-κB by thiol-enhancing action

DOI Web Site Web Site 被引用文献2件 参考文献71件
  • Go Eun Kyung
    Department of Pharmacy, College of Pharmacy
  • Jung Kyung Jin
    Department of Pharmacy, College of Pharmacy
  • Kim Ji Min
    Department of Pharmacy, College of Pharmacy
  • Lim Hyunae
    Department of Pharmacy, College of Pharmacy
  • Lim Hyeang Kwan
    Department of Pharmacy, College of Pharmacy
  • Yu Byung Pal
    Longevity Life Science and Technology Institutes, Pusan National University Department of Physiology, The University of Texas Health Science Center at San Antonio
  • Chung Hae Young
    Department of Pharmacy, College of Pharmacy Longevity Life Science and Technology Institutes, Pusan National University

書誌事項

タイトル別名
  • Betaine Modulates Age-Related NF-.KAPPA.B by Thiol-Enhancing Action
  • Betaine modulates age related NF kB by thiol enhancing action
  • Betaine modulates age-related NF-B by thiol-enhancing action

この論文をさがす

抄録

Depletion of glutathione levels and perturbations in redox status are considered to play a crucial role in aging and chronic inflammatory processes through the activation of redox sensitive transcription factors, including nuclear factor-κB (NF-κB). In the current study, we assessed the regulatory action of dietary betaine in the suppression of NF-κB by comparing kidney tissue from old, betaine-supplemented rats or non-betaine-supplemented rats (age 21 months) and 7 month-old rats. In addition, cultured HEK 293T cells were utilized for the molecular assessment of betaine's restorative ability of redox status when treating cells with potent glutathione (GSH)-depleting agents. Results showed that in old rats a short-term feeding (10 d) with betaine attenuated the age-related decrease in thiol levels, increase in reactive species and TNFα expression via NF-κB activation, compared to the young controls. These findings were verified in the cell-cultured system. Further investigations found that redox imbalance due to thiol depletion caused increased NF-κB activation, and cyclooxygenase (COX)-2 and TNFα levels, both of which were suppressed by betaine treatment. Based on both in vivo and in vitro data, we concluded that betaine exerts its efficacy by maintaining thiol status in the regulation of COX-2 and TNFα via NF-κB activation during aging.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (71)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ