Cytochrome P450 3As gene expression and testosterone 6β-hydroxylase activity in human fetal membranes and placenta at full term
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- Maezawa Kayoko
- Department of Pharmacy, Shinshu University Hospital
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- Matsunaga Tamihide
- Department of Pharmacy, Shinshu University Hospital
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- Takezawa Takashi
- Department of Pharmacy, Shinshu University Hospital
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- Kanai Makoto
- Department of Family and Child Nursing, and Midwifery
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- Ohira Satoshi
- Department of Obstetrics and Gynecology, Shinshu University School of Medicine
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- Ohmori Shigeru
- Department of Pharmacy, Shinshu University Hospital
書誌事項
- タイトル別名
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- Cytochrome P450 3As Gene Expression and Testosterone 6.BETA.-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term
- Cytochrome P450 3As gene expression and testosterone 6 v hydroxylase activity in human fetal membranes and placenta at full term
この論文をさがす
抄録
Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetal membranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained from pregnant women with normal delivery (5 subjects) and Caesarean section (15 subjects) were determined. These CYP3A mRNAs were also expressed in amnion and chorion/decidua together with placenta, although the expression level of these mRNAs was strikingly different between subjects. The expression level of the CYP3A4 mRNA in the placenta was about 2-fold higher than those in amnion and chorion/decidua. On the other hand, the expression levels of CYP3A5 and CYP3A7 mRNAs were highest in chorion/decidua. The immunologically related protein(s) with CYP3A7 was detected in all tissues examined. Testosterone 6β-hydroxylase activity in homogenate of human placenta, amnion and chorion/decidua were 26.6, 3.7 and 4.6 pmol/h/mg protein, respectively. These results suggest that CYP3As in fetal membranes have the metabolic function to protect the fetus from exposure to drugs.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (2), 249-254, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204625543424
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- NII論文ID
- 130000156632
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3c%2FmvFejug%3D%3D
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 10091/16950
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- NDL書誌ID
- 10536927
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- PubMed
- 20118548
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可