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Acute Exposure to Solar Simulated Ultraviolet Radiation Affects Oxidative Stress-Related Biomarkers in Skin, Liver and Blood of Hairless Mice
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- Rajnochová Svobodová Alena
- Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University
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- Galandáková Adéla
- Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University
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- Šianská Jarmila
- Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University
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- Doležal Dalibor
- Center for Laboratory Animals, Faculty of Medicine and Dentistry, Palacký University
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- Ulrichová Jitka
- Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University
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- Vostálová Jitka
- Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University
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Description
The ultraviolet (UV) region of solar radiation is a critical factor in the initiation and development of a number of skin diseases. However, it is not only skin which is directly exposed to solar light that is affected by UV radiation, through low molecular weight mediators, generated upon irradiation, “non-skin” tissues can also be affected. The aim of this study was to examine in detail, the acute effects of UVA and UVB wavebands on hairless mice. Female SKH-1 hairless mice were exposed to a single dose of UVB (200, 800 mJ/cm2) or UVA (10, 20 J/cm2) using a solar simulator. The effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of glutathione (GSH), markers of oxidative damage (lipid peroxidation and carbonylated proteins) were analysed in erythrocytes, plasma, liver and whole skin homogenates. No macroscopic changes were observed either 4 or 24 h after UVA/UVB exposure. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h following UVA and UVB irradiation, which disappeared 24 h after irradiation except for the higher UVA dose. Changes in oxidative stress-related parameters, particularly activity of catalase (CAT) and superoxide dismutase (SOD) and level of GSH and lipid peroxidation products, were found in skin, erythrocytes and liver. The expression of several enzymes (CAT, SOD, glutathione transferase (GST), nicotinamide adenine dinucleotide (phosphate) quinone oxidoreductase (NQO1) and hem oxygenase-1 (HO-1)) in skin was affected following UVA and UVB radiation. Increase in carbonylated proteins was found in plasma and skin samples.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 34 (4), 471-479, 2011
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204625588352
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- NII Article ID
- 130000657833
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 11025198
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed