Distribution of Dolichol in the Serum and Relationships between Serum Dolichol Levels and Various Laboratory Test Values
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- Shiota Yasuo
- Faculty of Pharmaceutical Sciences, Josai University
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- Kiyota Kengo
- Faculty of Pharmaceutical Sciences, Josai University
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- Kobayashi Teruaki
- Department of Clinical Laboratory, Tokyo Teishin Hospital
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- Kano Shojiro
- Department of Clinical Laboratory, Tokyo Teishin Hospital
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- Kawamura Mitsunobu
- Department of Internal Medicine, Tokyo Teishin Hospital
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- Matsushima Teruhiko
- Department of Internal Medicine, Tsukuba Memorial Hospital
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- Miyazaki Shigeru
- Department of Internal Medicine, Tokyo Teishin Hospital
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- Uchino Katsuyoshi
- Department of Pharmacy, Tokyo Teishin Hospital
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- Hashimoto Fumie
- Faculty of Pharmaceutical Sciences, Josai University
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- Hayashi Hidenori
- Faculty of Pharmaceutical Sciences, Josai University
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Abstract
We examined the correlations between serum dolichol levels and laboratory test parameters in patients affected by disease, as well as the distribution of dolichol in sera from patients with hyperbetalipoproteinemia and hyperalphalipoproteinemia. Serum dolichol was evaluated by a reverse-phase HPLC method. After centrifugation, the serum dolichol found in healthy controls was mainly associated with medium-sized particles of the high-density lipoprotein (HDL) fraction. For patients with hyperbetalipoproteinemia, serum dolichol was also associated with the medium HDL fractions. However, for hyperalphalipoproteinemia patients the levels of large HDL and serum dolichol were increased, and serum dolichol was mainly associated with the large HDL fraction. On laboratory tests of components, the dolichol level was not correlated with the values for markers of the liver and biliary system, with the values of renal function markers, with creatine kinase activity, amylase activity or uric acid concentration, but was correlated with total cholesterol, HDL-cholesterol and apoA-I concentrations, and with lactate dehydrogenase (LDH) activity. These results suggest that serum dolichol exclusively localized in HDL, and in subpopulation, that in normocholesterolemia or hyperbeta-cholesterolemia is associated with HDL3, which is small sized and high density HDL, however, that in hyperalphacholesterolemia is associated with HDL2, which is large sized and lower density HDL.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 31 (3), 340-347, 2008
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204625784704
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- NII Article ID
- 110006623053
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 9393027
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed