Strain- and Tissue-Dependent Induction of Plasminogen Activator Inhibitor-1 Gene Expression in Fasted Mice
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- Oishi Katsutaka
- Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology
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- Ohkura Naoki
- Clinical Molecular Biology, Faculty of Pharmaceutical Sciences, Teikyo University
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Plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of plasminogen activators, is an important contributor to hypofibrinolysis in the presence of metabolic disorders such as diabetes and obesity. The C57BLKS/J (BKS) inbred mouse strain is a popular animal model of type 2 diabetes. We previously described that food deprivation (FD) induces adipose PAI-1 expression in both lean BKS mice and BKS-db/db mice carrying a mutation in the leptin receptor gene. To evaluate the effects of the background of mouse strains, we examined FD-induced PAI-1 expression in the liver, heart and epididymal adipose tissues of BKS, C57BL/6J (B6), C3H/HeN and ICR mice. We found that PAI-1 expression is significantly induced in the heart and liver of fasted mice, although levels of expression in adipose tissues are strain-dependent. The effect of FD on plasma PAI-1 levels is also strain-dependent. Genetic background seems to be an important factor that should be considered when investigating thrombosis and fibrinolysis relative to metabolic changes in mice.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (3), 530-531, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204625943936
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- NII論文ID
- 130000248111
- 40017002089
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10582760
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可