Inhibitory Activity of Plant Stilbene Oligomers against DNA Topoisomerase 2

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  • Yamada Masashi
    Meiji Dairies Corporation
  • Hayashi Ken-ichiro
    Department of Biological Chemistry, Faculty of Science, Okayama University of Science
  • Ikeda Shogo
    Department of Biological Chemistry, Faculty of Science, Okayama University of Science
  • Tsutsui Ken
    Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
  • Tsutsui Kimiko
    Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University
  • Ito Tetsuro
    Gifu Prefectural Institute of Health and Environmental Sciences
  • Iinuma Munekazu
    Department of Pharmacognosy, Gifu Pharmaceutical University
  • Nozaki Hiroshi
    Department of Biological Chemistry, Faculty of Science, Okayama University of Science

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タイトル別名
  • Inhibitory Activity of Plant Stilbene Oligomers against DNA Topoisomerase II
  • Inhibitory activity of plant stilbene oligomers against DNA topoisomerase II (pharmacogosy)

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説明

The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topoisomerase II was assessed by their effect on DNA restriction enzyme. In particular, specific inhibitory activity was observed in α-viniferin 13-O-β-glucopryranoside (2) and hemsleyanol C (13).

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