Carrageenan Gels for Oral Sustained Delivery of Acetaminophen to Dysphagic Patients

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  • Miyazaki Shozo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Ishitani Mariko
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Takahashi Akie
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Shimoyama Tetsuya
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Itoh Kunihiko
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Attwood David
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester

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We have designed gel formulations for the oral administration of acetaminophen with suitable rheological characteristics for ease of administration to patients with swallowing difficulties and sufficient integrity in the stomach to achieve a sustained release of this drug. Gels formed by agar and ι-carrageenan were assessed for suitable gel strength and in vitro and in vivo release characteristics. Comparison of 1.5% ι-carrageenan gel with 0.5% agar gel demonstrated improved sustained release properties of the ι-carrageenan gel. Gel formed by ι-carrageenan has suitable rheological and sustained release characteristics for potential use as vehicles for oral delivery of drugs to dysphagic patients.

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