Inhibitory Effects of Stephania tetrandra S. MOORE on Free Radical-Induced Lysis of Rat Red Blood Cells
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- Sekiya Nobuyasu
- Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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- Hikiami Hiroaki
- Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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- Yokoyama Koichi
- Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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- Kouta Kazufumi
- Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
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- Sakakibara Iwao
- Pharmacognosy & Medicinal Resources Laboratory, Tsumura & Co.
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- Shimada Yutaka
- Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University 21st Century COE Program, Toyama Medical and Pharmaceutical University
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- Terasawa Katsutoshi
- 21st Century COE Program, Toyama Medical and Pharmaceutical University
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説明
Crude preparations of Stephania tetrandra S. MOORE (ST), a traditional herbal medicine, have been used safely for arthritis and silicosis in China. In this study, we demonstrated that ST in vitro protects red blood cells from 2,2-azo-bis (2-amidinopropane) dihydrochloride (AAPH)-induced hemolysis. The inhibitory effect was dose-dependent at concentrations of 10 to 1000 μg/ml. Moreover, tests were carried out to identify the main ingredient of ST that exerts a scavenging effect on free-radicals. Three representative alkaloids, tetrandrine, fangchinoline, and cyclanoline, isolated from ST, were found to have inhibitory activities against AAPH-induced lysis of red blood cells (RBC). Furthermore, the ingestion of 200 mg of ST extract was associated with a significant increase in free-radical scavenging effect of plasma in rats. These results suggest that ST as antioxidant inhibits AAPH-induced hemolysis of RBC both in vitro and in vivo.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 28 (4), 667-670, 2005
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204626125440
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- NII論文ID
- 10016662291
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 7292423
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- PubMed
- 15802807
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- 本文言語コード
- en
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- 資料種別
- journal article
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- NDLサーチ
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- PubMed
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