Rho-Rho Kinase Pathway Is Involved in the Protective Effect of Early Ischemic Preconditioning in the Rat Heart
-
- Sakamoto Kenji
- Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
-
- Nakahara Tsutomu
- Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
-
- Ishii Kunio
- Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
この論文をさがす
抄録
It has been shown that p38 mitogen-activated protein (MAP) kinase is absolutely necessary for the cardioprotection of early ischemic preconditioning in the heart. Reorganization of actin cytoskeleton after translocation of HSP27, which is mediated by p38 MAP kinase, was reported to be necessary for the cardioprotective effect of early ischemic preconditioning. Although Rho and Rho kinase are reported to regulate reorganaization of actin filaments, it is unknown whether Rho–Rho kinase pathway is involved in the cardioprotective effect of early ischemic preconditioning. The aim of the present study is to determine the involvement of Rho–Rho kinase pathway in the protective effect of early ischemic preconditioning in the rat hearts. Dominant-negative Rho significantly reduced the hypoxia-reoxygenation-induced activation of p38 MAP kinase, and constitutive active Rho activated p38 MAP kinase in rat myoblast H9c2 cells. Y-27632, a specific Rho kinase inhibitor, concentration-dependently attenuated the post-ischemic recovery of left ventricular developed pressure by early ischemic preconditioning. Thus, Rho–Rho kinase pathway is, at least in part, involved in the mechanism of early ischemic preconditioning.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 34 (1), 156-159, 2011
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204626163584
-
- NII論文ID
- 130000402281
-
- NII書誌ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 10927059
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可