PAP 9704, a Korean Herbal Medicine Attenuates Methamphetamine-Induced Hyperlocomotion via Adenosine A2A Receptor Stimulation in Mice
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- Kwon Yong Soo
- Neurotoxicology program, College of Pharmacy, Kangwon National University, Korea
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- Nabeshima Toshitaka
- Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine
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- Shin Eun-Joo
- Neurotoxicology program, College of Pharmacy, Kangwon National University, Korea
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- Chun Wanjoo
- Department of Pharmacology, College of Medicine, Kangwon National University, Korea
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- Jhoo Jin Hyeong
- Clinical Research Institute, Seoul National University Hospital, Korea
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- Jhoo Wang-Kee
- Neurotoxicology program, College of Pharmacy, Kangwon National University, Korea
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- Wie Myung Bok
- Department of Veterinary Medicine, Kangwon National University, Korea
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- Jang Choon-Gon
- College of Pharmacy, Sungkyunkwan University
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- Chung Heesun
- Division of Narcotic Analysis, The National Institute of Scientific Investigation, Korea
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- Sung Young Eun
- Neurotoxicology program, College of Pharmacy, Kangwon National University, Korea
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- Kim Hyoung-Chun
- Neurotoxicology program, College of Pharmacy, Kangwon National University, Korea
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Abstract
The effect of PAP 9704, a traditional prescription in Korea consisting of Polygala tenuifolia, Acorus gramineus, and Poria cocos at a ratio of 1 : 1 : 1 (dry weight), on methamphetamine (MA)-induced hyperlocomotion was examined in mice. The increased locomotor activity induced by MA (1 mg/kg/d, i.p.×7) was significantly attenuated by co-administration with PAP 9704 (100 or 200 mg/kg/d, p.o.×7) in a dose dependent manner. Consistently, it was found that the hyperlocomotor activity occurred in parallel with the expression of striatal fos-related antigen immunoreactivity. The adenosine A2A receptor antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (0.5 or 1.0 mg/kg, i.p.), significantly reversed the pharmacological action of PAP 9704 in a dose related manner, but the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (0.5 or 1.0 mg/kg, i.p.) and the A2B receptor antagonist alloxazine (1.5 or 3.0 mg/kg, i.p.) did not significantly affect this pharmacological action. Our results suggest that PAP 9704 prevents MA-induced hyperlocomotion, at least in part, via the stimulation of the adenosine A2A receptor.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 27 (6), 906-909, 2004
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204626219264
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- NII Article ID
- 110003608882
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6952352
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- PubMed
- 15187444
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed