Experimental Allergic Conjunctivities in Guinea Pigs Induced by Japanese Cedar Pollen.

DOI Web Site Web Site PubMed 3 Citations 16 References

Bibliographic Information

Other Title
  • Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen

Search this article

Abstract

We report a new experimental allergic conjunctivities with Japanese cedar pollen as antigen in guinea pigs, and the immunological characteristics of this model were also elucidated. Allergic conjunctivitis was developed by immunization in guinea pigs with a mixture containing Japanese cedar pollen and killed Bordetella pertussis. When local application of Japanese ceder pollen suspension 14 d after systemic immunization was performed every 3 d, remarkable conjunctivitis was observed from 20 to 35 d. Increase in vascular permeability and decrease in histamine contents of the conjunctiva were also observed after local application of antigen. Passive cutaneous anaphylactic (PCA) reactions revealed that both IgG- and IgE-rich antibodies were produced in this model. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting cedar pollen-induced conjunctivities. Although a high concentration was needed, tranilast and amlexanox also showed significant inhibition of conjunctivitis induced by cedar pollen.

Journal

Citations (3)*help

See more

References(16)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top