Feasibility of Transdermal Delivery of Prochlorperazine
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- Obata Yasuko
- Department of Pharmaceutics, Hoshi University
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- Otake Yuki
- Department of Pharmaceutics, Hoshi University
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- Takayama Kozo
- Department of Pharmaceutics, Hoshi University
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Abstract
Prochlorperazine (PCPZ) is used as a drug of first choice to treat opioid-induced nausea and vomiting. To examine the feasibility of the development of a transdermal drug delivery system for PCPZ, we performed an in vitro skin permeation study with hairless mouse skin. When the concentration of L-menthol in the hydrogel was 0—0.5%, the PCPZ flux was small; on the other hand, the flux was increased remarkably when the L-menthol concentration was higher than 1%. The optimal formulation of hydrogel would be contained 20% isopropanol (IPA), 10% N-methyl-2-pyrrolidone (NMP), 2% L-menthol and 1% PCPZ. The strong inhibitory effects to stereotyped behavior were observed at 4 h after administration of PCPZ hydrogel, and the efficacy was sustained for at least 8 h after the administration in mice in vivo. Thus, it was considered that PCPZ was delivered to brain via systemic circulation by the administration of PCPZ hydrogel.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 33 (8), 1454-1457, 2010
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204626655616
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- NII Article ID
- 130000300377
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- NII Book ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3cjis1Khsw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 10764782
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- PubMed
- 20686248
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed