Effects of Quercetin on Human α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor-Mediated Ion Currents

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  • Shin Tae-Joon
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University
  • Choi Sun-Hye
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University
  • Lee Byung-Hwan
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University
  • Pyo Mi Kyung
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University
  • Hwang Sung-Hee
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University
  • Kim Bo-Ra
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University
  • Lee Sang-Mok
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University
  • Han Ye Sun
    Advanced Technology Fusion, Konkuk University
  • Lee Jun-Ho
    Department of Physiology, College of Oriental Medicine, Kyung Hee University
  • Park Ji-Ho
    Graduate School of East-West Medical Science, Kyung Hee University
  • Kim Hyoung-Chun
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University
  • Rhim Hyewhon
    Life Science Division, Korea Institute of Science and Technology
  • Nah Seung-Yeol
    Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University

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タイトル別名
  • Effects of Quercetin on Human α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor-Mediated Ion Currents
  • Effects of quercetin on human a amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid receptor mediated ion currents

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抄録

Quercetin is a low molecular weight flavonoid found in dietary fruits and vegetables. Quercetin, like other flavonoids, has demonstrated neuroprotective effects in vitro and in vivo. However, relatively little is known about how quercetin achieves its neuroprotective abilities. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is one of several excitatory receptors, which play an important role in postsynaptic neurotransmission. Over-stimulation of ionotropic glutamate receptor including AMPA receptors is closely associated with excitatory neurotoxicities. In the present study, we investigated the effects of quercetin on the glutamate-induced inward current (IGlu) in Xenopus oocytes that heterologously express human AMPA receptor and stargazin, an auxiliary subunit of AMPA receptor. IGlu was measured using the two-electrode voltage clamp technique. In oocytes injected with cRNAs coding AMPA receptor (GluR1) and stargazin, quercetin inhibited IGlu in a reversible and concentration-dependent manner. The IC50 was 84.9±15.0 μM. Quercetin action on IGlu was attenuated by increasing glutamate concentration, and was membrane holding potential-dependent. These results show a possibility that quercetin interacts with AMPA receptor, which was heterologously expressed in Xenopus oocytes and that quercetin action on IGlu of AMPA receptor could be one of contributions of quercetin-mediated neuroprotections.

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