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Cry-Consensus Peptide, a Novel Peptide for Immunotherapy of Japanese Cedar Pollinosis, Induces Th1-Predominant Response in Cry j 1-Sensitized B10.S Mice
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- Kozutsumi Daisuke
- Research and Development Section, Pharmaceuticals Development Department, Meiji Dairies Corporation
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- Tsunematsu Masako
- Research and Development Section, Pharmaceuticals Development Department, Meiji Dairies Corporation
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- Yamaji Taketo
- Research and Development Section, Pharmaceuticals Development Department, Meiji Dairies Corporation
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- Murakami Rika
- Research and Development Section, Pharmaceuticals Development Department, Meiji Dairies Corporation
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- Yokoyama Minehiko
- Research and Development Section, Pharmaceuticals Development Department, Meiji Dairies Corporation
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- Kino Kohsuke
- Research and Development Section, Pharmaceuticals Development Department, Meiji Dairies Corporation
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Description
Cry-consensus peptide (CCP) is a newly designed peptide for peptide-based immunotherapy of Japanese cedar pollinosis but its mechanism of efficacy is unknown. We investigated the effect of CCP on Cry j 1-specific Th1/Th2 response in a mice model. Subcutaneous injection of CCP decreased Cry j 1-specific IgE and IgG1 in blood slightly, but the IgG2a level was increased significantly in a dose dependent manner. Splenocytes from these mice were stimulated with Cry j 1 in vitro. This inhibited IL-4, IL-5 and IL-10 secretion significantly, but IFN-γ secretion was increased. In vitro CCP stimulation of splenocytes from Cry j 1-sensitized mice induced more marked Th1-predominancy of cytokine production than native allergen stimulation. Taken together, these data suggest that one of the mechanisms of CCP is dependent on the modulation of the antigen-specific Th1/Th2 response.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 29 (12), 2506-2509, 2006
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204626808448
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- NII Article ID
- 110006148680
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 8548849
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed