The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in Vivo
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- Yamaguchi Tadatoshi
- Department of Hygiene, Miyazaki Medical College
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- Nomura Hajime
- Department of Laboratory Medicine, Miyazaki Medical College
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- Matsunaga Kazuhisa
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Ito Shigeru
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
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- Takata Jiro
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Karube Yoshiharu
- Faculty of Pharmaceutical Sciences, Fukuoka University
書誌事項
- タイトル別名
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- Behavior of Dihydropyrazine with DNA Strand Breakage Activity in Vivo
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抄録
The effects on the viability of cell lines treated with 2,3-dihydro-5,6-dimethylpyrazine and its derivatives, which revealed DNA strand-breakage activity by the generation of radicals in vitro, were recognized from certain morphological changes and the detection of apoptosis-related proteins: cleaved PARP and SAPK/JNK. These results would suggest that sugar-derived dihydropyrazines induce changes in the cells of certain organs and cause various internal injuries in vivo. The biodistribution of 14C-labelled 2,3-dihydro-5,6-dimethylpyrazine was studied in mouse and the autoradiograms showed highly contrasting results. Radioactivity was high in the brain, spinal cord, salivary gland, and thymus and low in the heart, stomach, and blood. The result was supported by the activity (% dose per organ).
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 26 (11), 1523-1527, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204626928512
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- NII論文ID
- 110003608339
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3sXpt1Crur4%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6723196
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- PubMed
- 14600394
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
