Icariin Derivative Inhibits Inflammation through Suppression of p38 Mitogen-Activated Protein Kinase and Nuclear Factor-.KAPPA.B Pathways
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- Chen Shao-Rui
- Laboratory of Pharmacology and Toxicology, Sun Yat-Sen University
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- Xu Xiang-Zhen
- Laboratory of Pharmacology and Toxicology, Sun Yat-Sen University
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- Wang Yu-Hua
- Laboratory of Pharmacology and Toxicology, Sun Yat-Sen University
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- Chen Jian-Wen
- Laboratory of Pharmacology and Toxicology, Sun Yat-Sen University
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- Xu Suo-Wen
- Laboratory of Pharmacology and Toxicology, Sun Yat-Sen University
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- Gu Lian-Quan
- Laboratory of Bioorganic and Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-Sen University
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- Liu Pei-Qing
- Laboratory of Pharmacology and Toxicology, Sun Yat-Sen University
Bibliographic Information
- Other Title
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- Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-κB pathways
- Icariin derivative inhibits inflammation through suppression of p38 mitogen activated protein kinase and nuclear factor k B pathways
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Abstract
In this study we investigated the anti-inflammatory effects of an icariin derivative (3,5-dihydroxy-4′-methoxy-6″,6″-dimethy1-4″,5″-dihydropyrano[2″,3″:7,8]-flavone). We found that this icariin derivative inhibits tumor necrosis factor-α (TNF-α) production, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression, and protein expression in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. It also alleviates paw edema induced by carrageenan in mice. To clarify the molecular mechanisms underlying these anti-inflammatory effects, we examined the effects of this compound on the phosphorylation of mitogen-activated protein kinase (MAPK), phosphorylation of inhibitory kappaBalpha (IκBα), and nuclear translocation of p65 subunit of nuclear factor (NF)-κB, and found it suppresses the activation of p38 MAPK and inhibits translocation of NF-κB p65 to the nucleus through decreasing the phosphorylation of IκBα. As a result of these properties, this icariin derivative can be considered as a potential drug for inflammatory diseases.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 33 (8), 1307-1313, 2010
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204627081088
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- NII Article ID
- 130000300352
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 10764520
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
