Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice

Abe Shinya, Suyama Satoko, Shishido Hitomi, Sato Masayoshi, Ohtake Yosuke, Sato Naoko, Ohkubo Yasuhito

doi:10.1248/bpb.27.1913

Gallium-67 (⁶⁷Ga) has been used as a tumor or inflammation-imaging agent in nuclear medicine. We recently reported that the peak of serum alanine aminotransferase (ALT) level was 1 d after carbon tetrachloride (CCl₄) treatment in rats. However, the peak of ⁶⁷Ga uptake by the liver tissue and hepatocytes was 2 d after the treatment. If ⁶⁷Ga is taken in the hepatic disorder phase, the pattern of ⁶⁷Ga uptake by the hepatocytes should be consistent with that of the ALT level. In order to answer why it was not, we carried out a detailed examination. The lipid peroxidation of hepatocytes from CCl₄-treated mice was greatly increased 1 d after CCl₄ treatment; serum ALT was also increased 1 d after the treatment. The uptake of ⁶⁷Ga by the liver tissue reached a maximum 1 and 2 d after the treatment, while maximum by the hepatocytes was achieved after 2 d. The incorporation of bromodeoxyuridine into the hepatocytes also reached maximum 2 d after the treatment. These results suggest that the uptake of ⁶⁷Ga by the hepatocytes is carried out during liver regeneration rather than during hepatic disorder by CCl₄ treatment.

Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice

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Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice

この論文をさがす

説明

収録刊行物

被引用文献 (3)*注記

参考文献 (33)*注記

キーワード

詳細情報 詳細情報について

書き出し

問題の指摘

詳細情報詳細情報について