Antidepressant Effects of a Plant-Derived Flavonoid Baicalein Involving Extracellular Signal-Regulated Kinases Cascade

  • Xiong Zhe
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
  • Jiang Bo
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
  • Wu Peng-Fei
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
  • Tian Jia
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
  • Shi Liang-Liang
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
  • Gu Jun
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology
  • Hu Zhuang-Li
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology Key Laboratory of Neurological Diseases (HUST), Ministry of Education, China Hubei Key Laboratory of Natural Drug Chemistry and Evaluation (HUST)
  • Fu Hui
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology Key Laboratory of Neurological Diseases (HUST), Ministry of Education, China Hubei Key Laboratory of Natural Drug Chemistry and Evaluation (HUST)
  • Wang Fang
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology Key Laboratory of Neurological Diseases (HUST), Ministry of Education, China Hubei Key Laboratory of Natural Drug Chemistry and Evaluation (HUST)
  • Chen Jian-Guo
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology Key Laboratory of Neurological Diseases (HUST), Ministry of Education, China Hubei Key Laboratory of Natural Drug Chemistry and Evaluation (HUST)

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説明

Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that baicalein (Bai), one plant-derived active flavonoid, exhibits neuroprotection against ischemic brain injury and stimulates the levels of phosphorylation of extracellular signal-regulated kinase (pERK) and brain-derived neurotrophic factor (BDNF) expression in vivo. In this study, the antidepressant-like effects of baicalein was investigated using acute and chronic animal models of depression. The results showed that acute application of Bai at doses of 1, 2 and 4 mg/kg by intraperitoneal injection (i.p.) significantly reduced the immobility time in the forced swimming test (FST) and tail suspending test (TST) of mice. In addition, the chronic application of Bai by i.p. for 21 d also reduced the immobility time and improved locomotor activity in chronic unpredictable mild stress (CMS) model rats. Furthermore, it was shown that Bai reversed the reduction of extracellular ERKs phosphorylation and the level of BDNF expression in the hippocampus of CMS model rats. These results suggest that Bai produce an antidepressant-like effect and this effect is at least partly mediated by hippocampal ERK-mediated neurotrophic action.

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