Compound K Inhibits Basic Fibroblast Growth Factor-Induced Angiogenesis via Regulation of p38 Mitogen Activated Protein Kinaseand AKT in Human Umbilical Vein Endothelial Cells
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- Jeong Arong
- College of Oriental Medicine, Kyung Hee University
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- Lee Hyo-Jung
- College of Oriental Medicine, Kyung Hee University
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- Jeong Soo-Jin
- College of Oriental Medicine, Kyung Hee University
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- Lee Hyo-Jeong
- College of Oriental Medicine, Kyung Hee University
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- Lee Eun-Ok
- College of Oriental Medicine, Kyung Hee University
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- Bae Hyunsu
- College of Oriental Medicine, Kyung Hee University
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- Kim Sung-Hoon
- College of Oriental Medicine, Kyung Hee University
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Compound K (CK; 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol), an active ginseng saponin metabolite, exerts anticancer activity via apoptosis induction in various cancers. In the present study, we investigated the anti-angiogenic activity of CK and its molecular mechanisms in human umbilical vein endothelial cells (HUVECs). Angiogenesis was induced in HUVECS by basic fibroblast growth factor (bFGF), a potent angiogenic growth factor. CK significantly inhibited the proliferation and also attenuated the expression of a proliferating protein cyclin D1 in bFGF treated HUVECs. Also, CK significantly inhibited the migration and tube formation of bFGF treated HUVECs at non-cytotoxic concentrations, reduced secreted level of vascular endothelial growth factor (VEGF) and increased the secreted level of pigment epithelium-derived factor (PEDF) in HUVECs. In addition, CK effectively disrupted bFGF-induced neo-vascularization in the Matrigel plugs excised from mice in vivo. Notably, we have found that CK downregulated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and AKT in bFGF treated HUVECs. Taken together, our findings for the first time indicate that CK exerts anti-angiogenic activity via inhibition of p38 MAPK and AKT in HUVECs with the potential of a cancer chemopreventive agent.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (6), 945-950, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204627523072
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- NII論文ID
- 130000247959
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10689112
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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