Oral Administration of Bifidobacterium bifidum G9-1 Suppresses Total and Antigen Specific Immunoglobulin E Production in Mice
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- Ohno Hiroshi
- Research & Development Department, Biofermin Pharmaceutical Co., Ltd.
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- Tsunemine Satoru
- Research & Development Department, Biofermin Pharmaceutical Co., Ltd.
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- Isa Yasuhiro
- Research & Development Department, Biofermin Pharmaceutical Co., Ltd.
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- Shimakawa Masaki
- Research & Development Department, Biofermin Pharmaceutical Co., Ltd.
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- Yamamura Hideki
- Research & Development Department, Biofermin Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- Oral administration of <italic>Bifidobacterium bifidum</italic> G9-1 suppresses total and antigen specific immunoglobulin E production in mice
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Abstract
Recent studies have suggested that oral bacteriotherapy with probiotics might be useful in the management of allergic diseases. We investigated the effect of oral administration of Bifidobacterium bifidum G9-1 (BBG9-1) on immunoglobulin (Ig) E production in BALB/c mice. Live BBG9-1 was orally administered to mice for 2 weeks from 1 week before ovalbumin (OVA)-immunization. The treatment of BBG9-1 significantly reduced serum total IgE level. In addition, BBG9-1 significantly and largely reduced the serum level of OVA-specific IgE without lowering of the specific IgG1 and increasing of the specific IgG2a. We also examined T helper type (Th) 1 and Th2 cytokine production from OVA-immunized splenocytes by restimulation with OVA in vitro. Productions of interferon (IFN)-γ, interleukin (IL)-4 and IL-5 from the splenocytes of mice given BBG9-1 were weaker than those of control mice. We conclude that oral administration of BBG9-1 selectively and powerfully suppresses total and antigen specific IgE production in mice. It is suggested that BBG9-1 is useful for the prophylactic treatment in IgE-dependent allergic diseases.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 28 (8), 1462-1466, 2005
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204627582720
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- NII Article ID
- 10016666974
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD2MXhtVWrsrrN
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 7372593
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- PubMed
- 16079493
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed