Natural trans-Crotonin: The Antiulcerogenic Effect of Another Diterpene Isolated from the Bark of Croton cajucara Benth.
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- Hiruma-Lima Clélia Akiko
- Departamento de Fisiologia, Instituto de Biociências, Universidade Estadual Paulista
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- Toma Walber
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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- Gracioso Juliano de Souza
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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- Almeida Ana Beatriz Albino de
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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- Batista Leônia Maria
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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- Magri Luciana
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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- Paula Ana Cláudia Bensuaski de
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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- Soares Fernanda Rocha
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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- Nunes Domingos Sávio
- Departamento de Química, Universidade Estadual de Ponta Grossa
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- Brito Alba Regina Monteiro Souza
- Departamento de Fisiologia e Biofisica, Instituto de Biologia, Universidade Estadual de Campinas
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Abstract
The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with another diterpene, DHC (trans-dehydrocrotonin) in the same models. When previously administered (p.o.) at the dose of 100 mg/kg, crotonin, as well as DHC, significantly reduced (p<0.05) gastric injury induced by stress (72, 67%), indomethacin/bethanechol (78, 29%) and pylorus ligature (35, 30%). In the HCl/ethanol-induced gastric ulcer model, at oral doses of 100 and 250 mg/kg, crotonin significantly prevented (p<0.05) the formation of gastric lesions by 51 and 56%, respectively, when compared to the control group. Gastric injury was also of significantly less magnitude in the DHC treatment group (p<0.05). In the pylorus-ligature model, crotonin (p.o.), like cimetidine, increased the volume of gastric juice when compared to the control group (p<0.05). No significant modifications where found in gastric parameters such as pH or total acid content after oral crotonin treatment. However, systemic alterations were observed when crotonin (100 mg/kg) was previously administered intraduodenally to mice. We observed significant changes (p<0.001) in gastric-juice parameters such as an increase in volume and a decrease in gastric acidity. Those pre-treated with crotonin as well as with DHC did not increase free mucus production (p>0.05). The results suggest that crotonin presents a significant anti-ulcer effect when assessed in these ulcer-induced models. As with DHC, the antiulcerogenic effects of crotonin are probably related to anti-secretory or/and gastroprotective properties of this substance. In light of results obtained with DHC and natural trans-crotonin in the present study, we concluded that the A-ring of both diterpenes is not directly involved in the antiulcerogenic activity.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 25 (4), 452-456, 2002
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204627722240
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- NII Article ID
- 110003638801
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- NII Book ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD38XkslWrs7o%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 6120693
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- PubMed
- 11995923
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed