Neuronal Ca〔2+〕/Calmodulin-Dependent Protein Kinase 2--Discovery, Progress in a Quarter of a Century, and Perspective: Implication for Learning and Memory

DOI Web Site Web Site PubMed 被引用文献11件 参考文献215件
  • Yamauchi Takashi
    Department of Biochemistry, Graduate School of Pharmaceutical Sciences, University of Tokushima

書誌事項

タイトル別名
  • Neuronal Ca2+/Calmodulin-Dependent Protein Kinase II-Discovery, Progress in a Quarter of a Century, and Perspective: Implication for Learning and Memory
  • Neuronal Ca 2 Calmodulin Dependent Protein Kinase 2 Discovery Progress in a Quarter of a Century and Perspective Implication for Learning and Memory

この論文をさがす

説明

Much has been learned about the activity-dependent synaptic modifications that are thought to underlie memory storage, but the mechanism by which these modifications are stored remains unclear. A good candidate for the storage mechanism is Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). CaM kinase II is one of the most prominent protein kinases, present in essentially every tissue but most concentrated in brain. Although it has been about a quarter of a century since the finding, CaM kinase II has been of the major interest in the region of brain science. It plays a multifunctional role in many intracellular events, and the expression of the enzyme is carefully regulated in brain regions and during brain development. Neuronal CaM kinase II regulates important neuronal functions, including neurotransmitter synthesis, neurotransmitter release, modulation of ion channel activity, cellular transport, cell morphology and neurite extension, synaptic plasticity, learning and memory, and gene expression. Studies concerning this kinase have provided insight into the molecular basis of nerve functions, especially learning and memory, and indicate one direction for studies in the field of neuroscience. This review presents the molecular structure, properties and functions of CaM kinase II, as a major component of neurons, based mainly developed on findings made in our laboratory.

収録刊行物

被引用文献 (11)*注記

もっと見る

参考文献 (215)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ