Metabolism of Constituents in Huangqin-Tang, a Prescription in Traditional Chinese Medicine, by Human Intestinal Flora

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  • Zuo Feng
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine
  • Zhou Zhong-Ming
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine
  • Yan Mei-Zhen
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine
  • Liu Mei-Lan
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine
  • Xiong Yu-Lan
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine
  • Zhang Qing
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine
  • Song Hong-Yue
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine
  • Ye Wen-Hua
    Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine

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Abstract

In the course of studies on the metabolism of active components of Huangqin-Tang by human intestinal flora (HIF), Huangqin-Tang and all individual herbs in the decoctions were incubated with a human fecal suspension separately. By using a high-performance liquid chromatographic (HPLC) method which was previously established in our laboratory, the metabolites in both the compound prescription and all the single herb decoctions were identified and determined both qualitatively and quantitatively. We found that the constituents of Huangqin-Tang, incluing baicalin (baicalein 7-glucuronide; BG), wogonoside (wogoninoglucuronide; WG), oroxylin-A-glucuronide (OG) from Scutellariae Radix, paeoniflorin (PF) from Paeoniae Radix, liquiritin (liquiritigenin 4′-O-glucoside; LG), isoliquirtin (isoliquiritigenin 4-glucoside; ILG) and glycyrrhizic acid (GL) from Glycyhhizea Radix, were converted to their metabolites baicalein (B), wogonin (W), oroxylin-A (O), paeonimetabolin-I (PM-I), liquiritigenin (L), isoliquiritigenin (IL) and glycyrrhetinic acid (GA) by HIF. The contents of the metabolites in Huangqin-Tang and in each single herb decoction increased significantly after incubation with intestinal flora. Comparing with single herb decoctions, the transformation of BG, WG, OG, LG and ILG in the compound prescription was promoted, however, that of PF and GL was inhibited. All the results suggested that the glycosides of many medicinal herbs could be converted to aglycones by HIF, and the metabolism of most glycosides was improved in the compound prescription.

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