A Tale of Early Response Genes

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  • Sng Judy Chia Ghee
    Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology
  • Taniura Hideo
    Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology
  • Yoneda Yukio
    Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology

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  • Tale of Early Response Genes

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Abstract

Immediate early genes (IEG) are rapidly but transiently induced directly by intracellular signaling cascades to alter patterns of gene expression. It has been proposed that histone modifications could be the key to the quick alteration of chromatin structure, as this spread occurs too rapidly to be the consequence of passage of RNA polymerase II. In this review, we will discuss the different modifications on histones and the chromatin remodeling enzymes, allowing the promoter regions of two IEGs, c-fos and c-jun, to be accessed.

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