Antidepressant-like effect of cordycept sinensis in the mouse tail suspension test

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  • Nishizawa Koji
    Noevir-Keio Research Laboratory, Noevir Co., Ltd.
  • Torii Kosuke
    Noevir-Keio Research Laboratory, Noevir Co., Ltd.
  • Kawasaki Aya
    Noevir-Keio Research Laboratory, Noevir Co., Ltd.
  • Katada Masanori
    Noevir-Keio Research Laboratory, Noevir Co., Ltd.
  • Ito Minoru
    Noevir-Keio Research Laboratory, Noevir Co., Ltd.
  • Terashita Kenzo
    Department of Cell Biology and Neuroscience, KEIO University School of Medicine Department of Anatomy, KEIO University School of Medicine
  • Aiso Sadakazu
    Department of Cell Biology and Neuroscience, KEIO University School of Medicine Department of Anatomy, KEIO University School of Medicine
  • Matsuoka Masaaki
    Department of Cell Biology and Neuroscience, KEIO University School of Medicine

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  • Antidepressant-Like Effect of <i>Cordyceps sinensis</i> in the Mouse Tail Suspension Test

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説明

Cordyceps sinensis (CS) has been known as a component of traditional medicines that elicit various biological effects such as anti-fatigue, immunomodulatory, and hypoglycemic actions. Since it has been well-established that fatigue is closely related to depression, we used the tail suspension test (TST) in mice to examine the antidepressant-like effects of hot water extract (HWCS) and supercritical fluid extract (SCCS) of CS. Immobility time in the TST was reduced by administration of SCCS (2.5—10 ml/kg, p.o.) dose-dependently though it was not reduced by treatment with HWCS (500—2000 mg/kg, p.o.). Neither HWCS nor SCCS altered locomotor activity in the open field test, excluding the possibility that the effect of SCCS is due to activation of locomotion. Pretreatment with prazosin (an adrenoreceptor antagonist) or sulpiride (a dopamine D2 receptor antagonist) reduced the effect of SCCS on the immobility time. In contrast, pretreatment with p-chlorophenylalanine (p-CPA, a serotonin synthesis inhibitor) did not alter the anti-immobility effect of SCCS. The last finding is consistent with an additional observation that SCCS had no effect on head twitch response induced by 5-hydroxy-L-tryptophan in mice. Taken altogether, these results suggest that SCCS may elicit an antidepressant-like effect by affecting the adrenergic and dopaminergic systems, but not by affecting the serotonergic system.

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