Tyrosinase Inhibitory Prenylated Flavonoids from Sophora flavescens
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- Kim Soo Jin
- College of Pharmacy, Kangwon National University, Korea
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- Son Kun Ho
- Department of Food Nutrition, Andong National University, Korea
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- Chang Hyun Wook
- College of Pharmacy, Yeungnam University
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- Kang Sam Sik
- Natural Products Institute, Seoul National University, Korea
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- Kim Hyun Pyo
- College of Pharmacy, Kangwon National University, Korea
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For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation. The ethanol extract and dichloromethane fraction from S. flavescens showed significant inhibition of mushroom tyrosinase. From the dichloromethane fraction, three known prenylated flavonoids, sophoraflavanone G, kuraridin, and kurarinone, were isolated. Compared with kojic acid (IC50=20.5 μM), these compounds possessed more potent tyrosinase inhibitory activity. The IC50 values were 6.6, 0.6, and 6.2 μM for sophoraflavanone G, kuraridin, and kurarinone, respectively.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 26 (9), 1348-1350, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204628511872
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- NII論文ID
- 110003608601
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BD3svislyjtQ%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6658412
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- PubMed
- 12951485
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可