Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor-α Carriers: Pharmacokinetics and Anti-tumor Effects

DOI Web Site Web Site PubMed 参考文献52件
  • LI Ya-Ping
    Department of Pharmaceutics, School of Pharmacy, Fudan University Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
  • PEI Yuan-Ying
    Department of Pharmaceutics, School of Pharmacy, Fudan University
  • ZHOU Zhao-Hui
    Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
  • ZHANG Xian-Ying
    Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
  • GU Zhou-Hui
    Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
  • DING Jian
    Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
  • ZHOU Jian-Jun
    Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences
  • GAO Xiu-Jian
    Department of Pharmaceutics, School of Pharmacy, Fudan University
  • ZHU Jian-Hua
    Department of Pharmaceutics, School of Pharmacy, Fudan University

書誌事項

タイトル別名
  • Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor-.ALPHA. Carriers: Pharmacokinetics and Anti-tumor Effects.
  • Stealth Polycyanoacrylate Nanoparticles as Tumor Necrosis Factor アルファ Carriers Pharmacokinetics and Anti tumor Effects
公開日
2001
資源種別
journal article
DOI
  • 10.1248/bpb.24.662
公開者
公益社団法人 日本薬学会

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説明

The objective of this study was to investigate the pharmacokinetics and in vivo anti-tumor effect of recombinant human tumor necrosis factor-α (rHuTNF-α) encapsulated in poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEG-PHDCA) nanoparticles. Our experimental results showed that PEG-PHDCA nanoparticles could extend the half-life of rHuTNF-α to 7.42 h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-α in tumor. Compared with PHDCA nanoparticles and free rHuTNF-α, PEG-PHDCA nanoparticles loaded with rHuTNF-α showed higher anti-tumor potency at the same dose, which might be related to its higher accumulation in tumor tissues and longer plasma circulation time. Therefore, PEG-PHDCA nanoparticles could be an effective carrier for rHuTNF-α.

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